Journal: Materials

Article Title: Forming Limit Stress Diagram Prediction of Pure Titanium Sheet Based on GTN Model

doi: 10.3390/ma12111783

Figure Lengend Snippet: SEM photos of commercially pure titanium (TA1) ( a ) original morphology; ( b ) measurement results.

Article Snippet: The annealed TA1 sheet with the thickness of 0.8 mm was provided by Shanxi Baoji Tengxin Titanium Industry Co., Ltd.

Techniques:

Journal: Materials

Article Title: Forming Limit Stress Diagram Prediction of Pure Titanium Sheet Based on GTN Model

doi: 10.3390/ma12111783

Figure Lengend Snippet: Nine groups damage parameters of TA1 in the finite element reverse calibration process.

Article Snippet: The annealed TA1 sheet with the thickness of 0.8 mm was provided by Shanxi Baoji Tengxin Titanium Industry Co., Ltd.

Techniques:

Journal: Materials

Article Title: Forming Limit Stress Diagram Prediction of Pure Titanium Sheet Based on GTN Model

doi: 10.3390/ma12111783

Figure Lengend Snippet: Forming limit diagram (FLD) and forming limit stress diagram (FLSD) of TA1 sheet ( a ) FLD; ( b ) FLSD.

Article Snippet: The annealed TA1 sheet with the thickness of 0.8 mm was provided by Shanxi Baoji Tengxin Titanium Industry Co., Ltd.

Techniques:

Journal: Materials

Article Title: Forming Limit Stress Diagram Prediction of Pure Titanium Sheet Based on GTN Model

doi: 10.3390/ma12111783

Figure Lengend Snippet: Comparison of FLD of TA1 between simulated and experimental results.

Article Snippet: The annealed TA1 sheet with the thickness of 0.8 mm was provided by Shanxi Baoji Tengxin Titanium Industry Co., Ltd.

Techniques: Comparison

Journal: Materials

Article Title: Forming Limit Stress Diagram Prediction of Pure Titanium Sheet Based on GTN Model

doi: 10.3390/ma12111783

Figure Lengend Snippet: Comparison of FLSD of TA1 between simulated and theoretical derivation.

Article Snippet: The annealed TA1 sheet with the thickness of 0.8 mm was provided by Shanxi Baoji Tengxin Titanium Industry Co., Ltd.

Techniques: Comparison

Journal: Scientific Reports

Article Title: Discovery and structural characterisation of new fold type IV-transaminases exemplify the diversity of this enzyme fold

doi: 10.1038/srep38183

Figure Lengend Snippet: Transaminase activities.

Article Snippet: Cpu TA1 exhibits the typical aminotransferase type IV fold (InterPro: IPR001544, Pfam: Pf01063).

Techniques: Activity Assay

Journal: Scientific Reports

Article Title: Discovery and structural characterisation of new fold type IV-transaminases exemplify the diversity of this enzyme fold

doi: 10.1038/srep38183

Figure Lengend Snippet: Conversions of rac -1-phenylethylamine, rac -1-aminotetralin or rac -1-aminoindane with pyruvate catalysed by the candidate enzymes after 24 h at 30 ° C.

Article Snippet: Cpu TA1 exhibits the typical aminotransferase type IV fold (InterPro: IPR001544, Pfam: Pf01063).

Techniques:

Journal: Scientific Reports

Article Title: Discovery and structural characterisation of new fold type IV-transaminases exemplify the diversity of this enzyme fold

doi: 10.1038/srep38183

Figure Lengend Snippet: Results of transaminase-catalysed amination reactions of pyruvate, α-ketoglutarate, glyoxylic acid, α-keto-γ-(methylthio)-butyrate and phenylpyruvate with rac -1-phenylethylamine, propan-2-amine, rac -butan-2-amine, cyclohexylamine and dl -alanine after 24 h at 30 °C.

Article Snippet: Cpu TA1 exhibits the typical aminotransferase type IV fold (InterPro: IPR001544, Pfam: Pf01063).

Techniques:

Journal: Scientific Reports

Article Title: Discovery and structural characterisation of new fold type IV-transaminases exemplify the diversity of this enzyme fold

doi: 10.1038/srep38183

Figure Lengend Snippet: Temperature dependence of specific activities calculated from photometric activity assays using 0.15 mg mL −1 of purified Cpu TA1 ( A ) or 0.1 mg mL −1 of Mgi TA1 ( B ) in 50 mM KPi, pH 8, at various T. The reaction mixtures (5 mM pyruvate, 5 mM ( R )-1-aminotetralin, 0.1 mM PLP in buffer) were incubated for 5 minutes at the respective temperature before addition of pyruvate to start the reaction. The measurements were done in triplicate. Grey diamonds: Cpu TA1, black triangles: Mgi TA1.

Article Snippet: Cpu TA1 exhibits the typical aminotransferase type IV fold (InterPro: IPR001544, Pfam: Pf01063).

Techniques: Activity Assay, Purification, Incubation

Journal: Scientific Reports

Article Title: Discovery and structural characterisation of new fold type IV-transaminases exemplify the diversity of this enzyme fold

doi: 10.1038/srep38183

Figure Lengend Snippet: ( A ) Overview of the Cpu TA1 dimer (chain A first domain in magenta, second domain in green, chain B in grey); ( B ) Overview of a superposition of the Cpu TA1 dimer (chain A in green, chain B in grey) with the AT-ωTA dimer (Pdb-code: 4CE5, chain A in turquoise, chain B in brown) with the active site cavity of Cpu TA1 depicted as magenta mesh; ( C ) PLP binding amino acids (blue); ( D ) active site amino acids (small binding pocket in yellow, large binding pocket in green); ( E ) entrance tunnel; ( F ) variable loops of Cpu TA1 compared to AT-ωTA. The cavity analysis was calculated by Casox . The figures were prepared using the program PyMOL (Schrodinger Inc.).

Article Snippet: Cpu TA1 exhibits the typical aminotransferase type IV fold (InterPro: IPR001544, Pfam: Pf01063).

Techniques: Binding Assay

Journal: British Journal of Pharmacology

Article Title: Histamine mediates behavioural and metabolic effects of 3-iodothyroacetic acid, an endogenous end product of thyroid hormone metabolism

doi: 10.1111/bph.12697

Figure Lengend Snippet: TA1 modifies learning, reduces nociceptive threshold and increases plasma glucose in mice. Mice (n = 20 for each groups of animals) were injected i.c.v. with TA1 (0.4, 1.32 or 4 μg·kg−1 or with Veh and, after 15 min, were assessed by the passive avoidance paradigm (A) or their nociceptive threshold measured by the the hot plate test (B). **P < 0.01, ***P < 0.001 versus Veh. Plasma glucose was also measured 15 min after TA1 injection, in blood collected from the tail veins of 4 h starved mice (n = 10 for r each groups of animals). Results are expressed as means ± SEM; *P < 0.05 versus Veh.

Article Snippet: Moreover, TA1 was recovered in mouse serum following i.p. administration of T1AM (Hackenmueller and Scanlan, 2012 ), supporting the concept that T1AM and TA1 are endogenous derivatives of the thyroid hormone and that the latter can be produced from the former.

Techniques: Clinical Proteomics, Injection, Hot Plate Test

Journal: British Journal of Pharmacology

Article Title: Histamine mediates behavioural and metabolic effects of 3-iodothyroacetic acid, an endogenous end product of thyroid hormone metabolism

doi: 10.1111/bph.12697

Figure Lengend Snippet: The effects of histamine H1 and H2 receptor antagonists on TA1-induced modification of learning, pain threshold and plasma glucose in mice. Mice (n = 20 for each groups of animals) were pretreated s.c. with a single injection of pyrilamine (10 mg·kg−1) or zolantidine [5 mg·kg−1, 15 min before the i.c.v. injection of T1A (0.4, 1.32 and 4 μg·kg−1) or Veh.]. 15 min after TA1 or Veh injection, mice were assessed by the passive avoidance paradigm (A), or nociceptive thresholds determined by the hot plate test (B). Plasma glucose was also measured 15 min after TA1 (0.4, 1.32 and 4 μg·kg−1) i.c.v. injection in the blood collected from the tail veins of 4 h starved mice (n = 10 for each treatment) (C). Results are expressed as means ± SEM. *P < 0.05, **P < 0.01,***P < 0.001 versus Veh.

Article Snippet: Moreover, TA1 was recovered in mouse serum following i.p. administration of T1AM (Hackenmueller and Scanlan, 2012 ), supporting the concept that T1AM and TA1 are endogenous derivatives of the thyroid hormone and that the latter can be produced from the former.

Techniques: Modification, Clinical Proteomics, Injection, Hot Plate Test

Journal: British Journal of Pharmacology

Article Title: Histamine mediates behavioural and metabolic effects of 3-iodothyroacetic acid, an endogenous end product of thyroid hormone metabolism

doi: 10.1111/bph.12697

Figure Lengend Snippet: TA1 reversed scopolamine-induced amnesia. TA1, 1.32 and 4 μg·kg−1 (n = 10 for each dose) or Veh were injected i.c.v. in mice (n = 20 for each groups of animals) pretreated i.p. with scopolamine (0.3 mg·kg−1, n = 30) or saline. Mice were then assessed by the passive avoidance paradigm. Results are expressed as means ± SEM. §P < 0.05 and §§§P < 0.001 versus Veh. + scopolamine, ***P < 0.001 versus Veh.

Article Snippet: Moreover, TA1 was recovered in mouse serum following i.p. administration of T1AM (Hackenmueller and Scanlan, 2012 ), supporting the concept that T1AM and TA1 are endogenous derivatives of the thyroid hormone and that the latter can be produced from the former.

Techniques: Injection, Saline

Journal: British Journal of Pharmacology

Article Title: Histamine mediates behavioural and metabolic effects of 3-iodothyroacetic acid, an endogenous end product of thyroid hormone metabolism

doi: 10.1111/bph.12697

Figure Lengend Snippet: T1A failed to induce hyperglycaemia and to raise plasma glucose when injected i.c.v. in HDC−/− mice. TA1 (1.32 and 4 μg·kg−1), or Veh, were injected i.c.v. in HDC+/+ and HDC−/− mice (n = 10 for each group of animals). After 15 min, nociceptive thresholds to a thermal stimulus and plasma glucose were evaluated in HDC+/+ (A and B) and in HDC−/− mice (C and D). Results are presented as the means ± SEM. *P < 0.05 versus Veh; **P < 0.01 versus Veh.

Article Snippet: Moreover, TA1 was recovered in mouse serum following i.p. administration of T1AM (Hackenmueller and Scanlan, 2012 ), supporting the concept that T1AM and TA1 are endogenous derivatives of the thyroid hormone and that the latter can be produced from the former.

Techniques: Clinical Proteomics, Injection